Innentitelbild: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. 23/2012)
نویسندگان
چکیده
منابع مشابه
6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes.
Decades of widespread clinical use of the bacterial ribosome A-site-targeting aminoglycosides (AGs) enhanced the evolution of resistance to these antibiotics and reduced their clinical efficacy. Three modes of action lead to bacterial resistance to AGs: reduction in the intracellular concentration of the antibiotics by efflux pump proteins or through reduced membrane permeability; structural mo...
متن کاملHopanoids as functional analogues of cholesterol in bacterial membranes.
The functionality of cellular membranes relies on the molecular order imparted by lipids. In eukaryotes, sterols such as cholesterol modulate membrane order, yet they are not typically found in prokaryotes. The structurally similar bacterial hopanoids exhibit similar ordering properties as sterols in vitro, but their exact physiological role in living bacteria is relatively uncharted. We presen...
متن کاملSpotlights on our sister journals: Angew. Chem. Int. Ed. 15/2018.
MAC it happen : Presented is a study of the synergistic structuredirecting effect of metal–amine complexes (MACs) with different chelating polyamine ligands and imidazolium-based ionic liquid (IL) cations. For the first time, a layered selenidostannate with an asymmetric eight-membered ring, an organic-decorated layered selenidostannate, and a 3D selenidostannate with both the MAC and IL cation...
متن کاملSelective recognition of bacterial membranes by zinc(II)-coordination complexes.
Two fluorophore-dipicolylamine-Zn2+ conjugates are shown by epifluorescence microscopy to stain the membranes of bacterial cells in preference to mammalian cells.
متن کاملAntimicrobial agents targeting bacterial cell walls and cell membranes.
Antimicrobial agents that target the bacterial cell wall or cell membrane have been used effectively for the past 70 years. Among the agents that inhibit bacterial cell wall synthesis, the beta-lactam antibiotics have emerged into broad-spectrum agents that inhibit most pathogenic bacteria, but are now being threatened by the rapid spread of drug-inactivating beta-lactamases. Glycopeptides stil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2012
ISSN: 0044-8249
DOI: 10.1002/ange.201203240